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Rosalind Franklin, Chemist, Molecular Biologist

"Science, for me, gives a partial explanation for life. In so far as it goes, it is based on fact, experience and experiment."

PEER REVIEWED ARTICLES

 

Kanojia S, Davidson RK, Conley JM, Xu J, Osmulski M, Sims EK, Ren H, Spaeth JM. Dynamic regulation of pancreatic β cell function and gene expression by the SND1 coregulator in vitro. Islets. 2023 Dec 31;15(1):2267725. PMID: 37838950; PMCID: PMC10578191

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Davidson RK, Kanojia S, Wu W, Kono T, Xu J, Osmulski M, Bone R, Casey N, Evans-Molina C,Sims EK, Spaeth JM. The Chd4 helicase regulates chromatin accessibility and gene expression critical for β-cell function in vivo. Diabetes. 2023 Mar 13;db220939. PMID: 36913741

 

Davidson RK, Weaver SA, Casey N, Kanojia S, Hogarth E, Schneider Aguirre R, Sims EK, Evans-Molina C, Spaeth JM. The Chd4 subunit of the NuRD complex regulates Pdx1-controlled genes involved in β-cell function. J Mol Endocrinol. 2022 Jun 14;69(2):329-341. PMID: 35521759; PMCID: PMC9260723

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Spaeth JM, Liu J-H, Peters D, Guo M, Osipovich AB, Mohammadi F, et al. The Pdx1 Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet β Cell Function. Diabetes. 2019 Jun 14;db190349. PMID: 31201281

 

Wilson CS, Spaeth JM, Karp J, Stocks BT, Hoopes EM, Stein RW, et al. B lymphocytes protect islet β cells in diabetes-prone NOD mice treated with imatinib. JCI Insight. 2019 May 2;4(9). PMCID: PMC6538336

 

Russell MA, Redick SD, Blodgett DM, Richardson SJ, Leete P, Krogvold L, Dahl-Jørgensen K, Bottino R, Brissova M, Spaeth JM, et al. HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet β-Cells From Donors With Type 1 Diabetes. 2019 May;68(5):988-1001. PMID: 30833470.

 

Park MJ, Shen H, Spaeth JM, Tolvanen JH, Failor C, Knudtson JF, et al. Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of Cyclin C-CDK8/19. J Biol Chem. 2018 Feb 13;jbc.RA118.001725. PMID: 29440396.

 

Spaeth JM*, Gupte M*, Perelis M, et al. Defining a Novel Role for the PDX1 Transcription Factor in Islet β Cell Maturation and Proliferation During Weaning. Diabetes. 2017;db161516. PMCID: PMC5652607. * = Equal contributions

 

Dean ED, Li M, Prasad N, Wisniewski SN, Von Deylen A, Spaeth J, et al. Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation. Cell Metab. 2017 Jun;25(6):1362–1373.e5. PMCID: PMC5572896.

 

Conrad E, Dai C, Spaeth J, et al. The MAFB transcription factor impacts islet α-cell function in rodents and represents a unique signature of primate islet β-cells. Am J Physiol Endocrinol Metab. 2016. 310 (1): E91–102. PMCID: PMC4675799.

 

Spaeth JM*, Hunter CS*, Bonatakis L, et al. The FOXP1, FOXP2 and FOXP4 transcription factors are required for islet alpha cell proliferation and function in mice. Diabetologia 2015:1–9. PMCID: PMC4785827. * = Equal contributions
 

Turunen M, Spaeth JM, Keskitalo S, et al. Uterine Leiomyoma-Linked MED12 Mutations Disrupt Mediator-Associated CDK Activity. Cell Reports 2014;7(3):654–660. PMCID: PMC4041330. Equal contributions.

 

Zhou H, Spaeth JM , Kim NH, et al. MED12 mutations link intellectual disability syndromes with dysregulated GLI3-dependent Sonic Hedgehog signaling. Proceedings of the National Academy of Sciences 2012;109(48):19763–19768. PMCID: PMC3511715.

 

Krebs P, Fan W, Chen Y-H, Tobita K, Downes MR, Wood MR, Sun L, Li X, Xia Y, Ding N, Spaeth JM, et al. 2011. Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet. Proceedings of the National Academy of Sciences 2011;108:19678–19682. PMCID: PMC3241770.

 

REVIEW ARTICLES

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Davidson RK, Kanojia S, Spaeth JM. The Contribution of Transcriptional Coregulators in the Maintenance of β-cell Function and Identity. Endocrinology. 2021 Feb 1;162(2):bqaa213. doi: 10.1210/endocr/bqaa213. PMID: 33211800.

 

Spaeth JM, Walker EM, Stein R. Impact of Pdx1-associated chromatin modifiers on islet β-cells. Diabetes Obes Metab. 2016 Sep

1;18:123–7. PMID: 27615141

 

Spaeth JM, Kim NH, Boyer TG. Mediator and human disease. Seminars in Cell & Developmental Biology 2011;22(7):776–787. PMCID: PMC4100472

 

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