PEER REVIEWED ARTICLES

 

Davidson, R.K., Wu, W., Kanojia, S., George, R.M., Sandoval, K., Osmulski, M., Casey, N., Spaeth, J.M. The SWI/SNF chromatin remodeling complex regulates pancreatic endocrine cell expansion and differentiation in mice in vivo. Diabetologia (2024). https://doi.org/10.1007/s00125-024-06211-7

​

Kanojia S, Davidson RK, Conley JM, Xu J, Osmulski M, Sims EK, Ren H, Spaeth JM. Dynamic regulation of pancreatic β cell function and gene expression by the SND1 coregulator in vitro. Islets. 2023 Dec 31;15(1):2267725. PMID: 37838950; PMCID: PMC10578191

​

Davidson RK, Kanojia S, Wu W, Kono T, Xu J, Osmulski M, Bone R, Casey N, Evans-Molina C,Sims EK, Spaeth JM. The Chd4 helicase regulates chromatin accessibility and gene expression critical for β-cell function in vivo. Diabetes. 2023 Mar 13;db220939. PMID: 36913741

 

Davidson RK, Weaver SA, Casey N, Kanojia S, Hogarth E, Schneider Aguirre R, Sims EK, Evans-Molina C, Spaeth JM. The Chd4 subunit of the NuRD complex regulates Pdx1-controlled genes involved in β-cell function. J Mol Endocrinol. 2022 Jun 14;69(2):329-341. PMID: 35521759; PMCID: PMC9260723

​

Spaeth JM, Liu J-H, Peters D, Guo M, Osipovich AB, Mohammadi F, et al. The Pdx1 Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet β Cell Function. Diabetes. 2019 Jun 14;db190349. PMID: 31201281

 

Wilson CS, Spaeth JM, Karp J, Stocks BT, Hoopes EM, Stein RW, et al. B lymphocytes protect islet β cells in diabetes-prone NOD mice treated with imatinib. JCI Insight. 2019 May 2;4(9). PMCID: PMC6538336

 

Russell MA, Redick SD, Blodgett DM, Richardson SJ, Leete P, Krogvold L, Dahl-Jørgensen K, Bottino R, Brissova M, Spaeth JM, et al. HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet β-Cells From Donors With Type 1 Diabetes. 2019 May;68(5):988-1001. PMID: 30833470.

 

Park MJ, Shen H, Spaeth JM, Tolvanen JH, Failor C, Knudtson JF, et al. Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of Cyclin C-CDK8/19. J Biol Chem. 2018 Feb 13;jbc.RA118.001725. PMID: 29440396.

 

Spaeth JM*, Gupte M*, Perelis M, et al. Defining a Novel Role for the PDX1 Transcription Factor in Islet β Cell Maturation and Proliferation During Weaning. Diabetes. 2017;db161516. PMCID: PMC5652607. * = Equal contributions

 

Dean ED, Li M, Prasad N, Wisniewski SN, Von Deylen A, Spaeth J, et al. Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation. Cell Metab. 2017 Jun;25(6):1362–1373.e5. PMCID: PMC5572896.

 

Conrad E, Dai C, Spaeth J, et al. The MAFB transcription factor impacts islet α-cell function in rodents and represents a unique signature of primate islet β-cells. Am J Physiol Endocrinol Metab. 2016. 310 (1): E91–102. PMCID: PMC4675799.

 

Spaeth JM*, Hunter CS*, Bonatakis L, et al. The FOXP1, FOXP2 and FOXP4 transcription factors are required for islet alpha cell proliferation and function in mice. Diabetologia 2015:1–9. PMCID: PMC4785827. * = Equal contributions
 

Turunen M, Spaeth JM, Keskitalo S, et al. Uterine Leiomyoma-Linked MED12 Mutations Disrupt Mediator-Associated CDK Activity. Cell Reports 2014;7(3):654–660. PMCID: PMC4041330. Equal contributions.

 

Zhou H, Spaeth JM , Kim NH, et al. MED12 mutations link intellectual disability syndromes with dysregulated GLI3-dependent Sonic Hedgehog signaling. Proceedings of the National Academy of Sciences 2012;109(48):19763–19768. PMCID: PMC3511715.

 

Krebs P, Fan W, Chen Y-H, Tobita K, Downes MR, Wood MR, Sun L, Li X, Xia Y, Ding N, Spaeth JM, et al. 2011. Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet. Proceedings of the National Academy of Sciences 2011;108:19678–19682. PMCID: PMC3241770.

 

REVIEW ARTICLES

​

Davidson RK, Kanojia S, Spaeth JM. The Contribution of Transcriptional Coregulators in the Maintenance of β-cell Function and Identity. Endocrinology. 2021 Feb 1;162(2):bqaa213. doi: 10.1210/endocr/bqaa213. PMID: 33211800.

 

Spaeth JM, Walker EM, Stein R. Impact of Pdx1-associated chromatin modifiers on islet β-cells. Diabetes Obes Metab. 2016 Sep

1;18:123–7. PMID: 27615141

 

Spaeth JM, Kim NH, Boyer TG. Mediator and human disease. Seminars in Cell & Developmental Biology 2011;22(7):776–787. PMCID: PMC4100472

 

​